(18), and in our own internal NSCLC dataset, levels of TIGIT among cytotoxic T cells were highest in terminally exhausted T cells within the tumor bed, which supports the notion that relief of the TIGIT checkpoint alone through antibody-mediated blockade would likely be insufficient to drive antitumor responses, given that these cells lack any further reactivation potential. This evidence concerns the gene TIGIT and non-small cell lung carcinoma.