Reanalysis of published single-cell RNA sequencing (scRNA-seq) data (18) of tumor-infiltrating T cells from patients with non-small cell lung cancer (NSCLC) showed TIGIT prominently expressed by resting and suppressive Tregs (CD4 subsets 8-FOXP3 and 9-CTLA-4, respectively), exhausted CD4+ T cells (CD4 subset C7-CXCL13), and exhausted CD8+ T cells (CD8 subset C6-LAYN) (Figure 1A). This evidence concerns the gene CD4 and neoplasm.