For instance, previous study has demonstrated a significant decrease in the mRNA expression levels of four specific genes (interleukin-8 (IL-8), transforming growth factor-β (TGF-β), tissue inhibitor of mental protease 1 (TIMP-1), and zeta chain of T cell receptor associated protein kinase 70 (ZAP-70)), within exosomes derived from the bodily fluids of glioma patients undergoing therapeutic interventions (39). This evidence concerns the gene CXCL8 and central nervous system cancer.