TNF and obesity due to melanocortin 4 receptor deficiency: Moreover, investigations on a potential immunoregulatory role of F. plautii based on mouse models revealed it to inhibit the Th2 immune response, TNF-α expression and interleukin (IL)-17 signaling, thus, potentially alleviating inflammatory responses in allergic diseases, adipose tissue in obesity, and gut inflammation, respectively (67–69).