Additionally, putrescine, whose production was elevated in BP patients, was reported to be a disrupter of intestinal barrier function, with its oral administration increasing gut permeability in mice (47), and furthermore to have immunoregulatory potential such as increasing anti-inflammatory macrophages in the colon and positively correlating with the proinflammatory chemokine CXCL8 in psoriasis patients (48, 49). The gene discussed is CXCL8; the disease is psoriasis.