This was associated with the inhibition of both serum and renal tissue levels of HMGB1 and expression of Mincle in the diabetic kidney of db/db mice (Figures 1D-F), suggesting that treatment with quercetin may inhibit the release of DAMPs such as HMGB1 from necrotic renal tubular cells and thus suppresses M1 macrophage activation and renal inflammation. This evidence concerns the gene HMGB1 and urogenital neoplasm.