CLEC4E and medical procedure: This was associated with the inhibition of both serum and renal tissue levels of HMGB1 and expression of Mincle in the diabetic kidney of db/db mice (Figures 1D-F), suggesting that treatment with quercetin may inhibit the release of DAMPs such as HMGB1 from necrotic renal tubular cells and thus suppresses M1 macrophage activation and renal inflammation.