Interestingly, although treatment with quercetin did not alter the expression of TLR-4 (Figures 4A, B), it did significantly suppress Mincle expression (Figure 1F) and therefore inhibited phosphorylation of Syk and NF-κB/p65 in the diabetic kidney of SARS-CoV-2 N protein-induced AKI (Figure 4). Here, TLR4 is linked to acute kidney injury.