reported that dsDNA-specific IgE antibodies activated plasmacytoid dendritic cells (pDCs) in SLE, resulting in the production of substantial amounts of IFN-α (a cytokine closely related to the degree of SLE activity), and TLR9 mediated dsDNA sensing (185, 186). The gene discussed is IFNA1; the disease is systemic lupus erythematosus.