To investigate the potential mechanisms that link the comorbidity of obesity and depression to the poor prognosis in these adolescents, we compared CBC parameters, inflammatory ratios, and levels of proinflammatory cytokines (IFN-γ, IL-1β, IL-6, IL-8, MCP-1, and TNF-α) and anti-inflammatory cytokine [TGF-β1]) between the different BMI groups. This evidence concerns the gene CXCL8 and major depressive disorder.