All AEs were similar in two groups.Grade 3-4 AEs: anemia (17% vs 6%), neutropenia (17% vs 1%), thrombocytopenia (34% vs 12%), anorexia (14% vs 6%).More frequent in sorafenib group: alopecia, hoarseness, diarrhea and elevated alanine aminotransferase.More frequent in combination group: nausea, vomiting and decreased white cell count. This evidence concerns the gene GPT and neutropenia.