Grade 3–4 AEs: neutropenia (8.5% vs 1.2%), thrombocytopenia (5.6% vs 0%), nausea (5.6% vs 0%). Any grade liver dysfunction (elevated ALT, elevated AST, hyperbilirubinemia, hypoalbuminemia) was more frequent in combination group. This evidence concerns the gene GPT and Thrombocytopenia.