Grade 1-2 AEs: fatigue (69%), hypophosphatemia (64%), diarrhea (59%), ALT elevation (56%), nausea (54%), thrombocytopenia (46%).Grade 3 AEs: AST elevation (28%), ALT elevation (15%), diarrhea (13%), bilirubin (10%), anemia (10%), hand-foot syndrome (8%), bleeding (8%). This evidence concerns the gene GPT and anemia (phenotype).