Mutations in catenin beta 1 (CTNNB1) were negatively associated with the prognosis of HCC in the context of alcohol intake (8), while missense mutations of tumor protein p53 (TP53) were shown to be negatively associated with the prognosis of HCC in the context of hepatitis B virus infection (9). The gene discussed is CTNNB1; the disease is hepatitis B virus infection.