Stimulated by acetylcholine, R was significantly enhanced and C was decreased in the asthma group compared with the control group (Figures 1G, H; P < 0.01), while R was significantly decreased and C was enhanced in the anti-Sema7a group mice compared with the asthma group mice (Figures 1G, H; P < 0.01). The gene discussed is SEMA7A; the disease is asthma.