found that OSM treatment not only promoted RA-FLS to secrete IL-6, but also promoted RA-FLS to secrete the pro-inflammatory cytokines IL-8, chemokine C-C Motif Chemokine Ligand 2 (CCL2), and adhesion molecule ICAM-1 (65, 66). This evidence concerns the gene ICAM1 and rheumatoid arthritis.