Analysis outcomes revealed that the group age over 65 (HR = 1.067, 95% CI = 1.053-1.080, P< 0.001), with a higher tumor grade (HR = 4.899, 95% CI = 3.633-6.605, P< 0.001), 1p/19q non-codel status (HR = 0.312, 95% CI = 0.196-0.494, P< 0.001), IDH1 wild type (HR = 5.660, 95% CI = 4.084-7.843, P< 0.001), and a higher risk score (HR = 1.011, 95% CI = 1.009-1.013, P< 0.001), exhibited a notably reduced OS (Figure 8A). The gene discussed is IDH1; the disease is neoplasm.