Evidence against this interpretation includes the observations: (i) that most of our participants with CD4 lymphopaenia had no other features to suggest intestinal lymphangiectasia and, (ii) that lymphopaenia was considerably more prevalent in PLA patients than hypoalbuminaemia or hypoglobulinaemia - generally considered hallmarks of intestinal lymphangiectasia, (Figures 2, S5; Table S5). This evidence concerns the gene CD4 and Hypoalbuminemia.