Investigations in patients with intestinal lymphangiectasia, not uncommonly associated with PLA, show depletion of CD4+ T-lymphocytes from blood with a preferential loss of naïve versus memory cells and a skewing of cytokine responses in memory cells towards a less inflammatory profile (more IL-4; less IFN-γ/IL-2) (11). The gene discussed is CD4; the disease is intestinal lymphangiectasia.