Also, it has been determined that in HCC-associated MSCs, a high expression level of lncRNA-MUF is observed; this lncRNA binds with Annexin A2 (ANXA2) and activates Wnt/b-catenin and causes their signaling and overexpression of miR-34a increases hence hepatocarcinogenesis (122). Here, ANXA2 is linked to hepatocellular carcinoma.