One aspect of MCs’ function as cancer promoters is to stimulate angiogenesis, lymphangiogenesis, and degradation of ECM by releasing a wide range of pro-angiogenic molecules [vascular endothelial growth factors (VEGFs), histamine, heparin, and stem cell factor (SCF)] (70–74), lymphangiogenic molecules (75), proteases, and matrix metalloproteinase-9 (MMP-9) (76–78). This evidence concerns the gene MMP9 and cancer.