Still, the SYSCID map encodes a novel function for pro-apoptotic protein BCL2L11 in SLE (46); this protein suppresses pro-inflammatory macrophage activity by inhibiting TBK1 kinase that, in turn, activates IRF3, a transcription factor that promotes the expression of several pro-inflammatory proteins (47). The gene discussed is BCL2L11; the disease is systemic lupus erythematosus.