CD4 and rheumatoid arthritis: Although the available data suggest that DCs, MDSCs, M2 macrophages, CD4+ and CD8+ T cells, and, in part, adipokines can activate ECs and promote ECs proliferation and migration, further studies are necessary to verify the effects of Notch signaling regulated by glycosylation, ubiquitination, SUMOylation, and lncRNAs/miRNAs on RA angiogenesis.