SPARC-overexpressing neuroblastoma cells inhibit the expression of Notch signaling and VEGFR2 phosphorylation and suppress tumor-induced angiogenesis by limiting the formation of endothelial capillary-like tubules, the proliferation of ECs, and the generation of pro-angiogenic factors, including VEGF, FGF, PDGF, and MMP-9 (129). The gene discussed is MMP9; the disease is neoplasm.