All VOCs included in this study have emerged from mutations in the S protein of the Wuhan strain (35) that had already been described as means of immune evasion for neutralizing antibodies (54, 55), but this data indicates that the antiviral cellular immune response against S protein could also be compromised, explaining the protection against severe cases of COVID-19, but not against viral infection (56). This evidence concerns the gene PROS1 and viral infectious disease.