Factors such as high disease activity, prolonged disease duration, and poor functionality as measured by the Health Assessment Questionnaire (HAQ) contribute to osteoporosis risk in RA [2,7]. Proinflammatory cytokines such as TNF-α, IL-1, IL-6, and IL-17 that are upregulated in RA enhance osteoclastogenesis [8,9]. The gene discussed is TNF; the disease is rheumatoid arthritis.