Edema: spontaneous and induced pain, erythema: functional limitation, hematoma: sensation of heaviness, ulcers: paresthesias, nocturnal cramps: cutaneous dyscrasias, induration: vein turgor. Laboratory parameters: coagulation time, PTT, PT, ESR, red blood cells, hematocrit, hemoglobin, white blood cells, platelets, CRP. The gene discussed is CRP; the disease is hematoma.