PDGFRA and neoplasm: It is believed that GIST results from a mutated KIT gene, which is a proto-oncogene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, cluster of differentiation 117 (CD117), or mast/stem cell growth factor receptor (SCFR), and/or platelet-derived growth factor receptor alpha (PDGFRA) polypeptide, leading to higher rates of cell division and eventually tumor [2].