GPT and metabolic dysfunction-associated steatotic liver disease: However, this corresponded to a lowered AST/ALT ratio (AAR), a known biomarker of NAFLD. Based on the findings of Van Wyk and Wink, the administration of silymarin in a dosage range of 200 to 400 mg per day has been deemed efficacious in the treatment of various liver disorders [45]. None of the studies have definitively determined the suitable daily dosage, with only 13.8% of them falling within the range of 200-400 mg.