TNFSF11 and breast carcinoma: Liensinine and nuciferine, present in Nelumbo nucifera,were reported to inhibit the receptor activator of nuclear factor kappa-B ligand-induced osteoclast differentiation in mouse bone marrow macrophage cells and mature osteoclast-mediated bone resorption which inhibits the growth of breast cancer cells and breast cancer-associated bone loss [20].