Contrarily, immune-mediated thrombocytopenia is brought on by the development of antibodies that react with platelet-specific glycoprotein complexes, as in the case of classic drug-induced immune thrombocytopenia (DITP), or with platelet factor 4, as in the case of heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombocytopenia (VITT) [75,76]. The gene discussed is PF4; the disease is autoimmune thrombocytopenic purpura.