This systemic review revealed older age, male gender, previous abdominal surgeries, acute cholecystitis, symptom duration of more than 72 hours, previous history of acute cholecystitis, diabetes, obesity, emergency LC, and CRP value >76 mg/L to be significant preoperative risk factors for conversion from LC to OC. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.