We found that older age, male gender, previous abdominal surgeries, acute cholecystitis, symptom duration of more than 72 hours, previous history of acute cholecystitis, CRP value, CLOC score more than 6, G10 cholecystitis severity score more than 3, diabetes, obesity, emergency LC, and urgent admissions are significant risk factors for conversion of LC to OC. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.