The US FDA approved the use of Chinese yam polysaccharide poly (lactic-co-glycolic acid) to develop vaccine delivery systems due to its demonstrated immune regulation and immune potentiation properties [66].Prebiotics have been shown to be beneficial in not only improving common GI symptoms like diarrhea and constipation [67] but also in improving insulin sensitivity [14] in overweight and obese adults, lowering the risk of type 2 diabetes mellitus (T2DM) [15, 68], obesity and hyperlipidemia [16, 69]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.