The major allele of rs1049305, located in the 3’-untranslated region of the AQP1 gene, was reported to be a risk SNP for malignant mesothelioma [15], and the minor allele of rs1049305 was associated with water retention in cirrhotic patients [16] and running performance in marathons [17]. Here, AQP1 is linked to malignant mesothelioma.