RA: rheumatoid arthritis; FRS: Framingham 10-year cardiovascular risk Score; CV: cardiovascular; HS-cTnT: high-sensitive cardiac troponin T; NT-proBNP: N-terminal pro-brain natriuretic peptide; BNP: brain natriuretic peptide. The gene discussed is TNNT2; the disease is rheumatoid arthritis.