High expression of CXCL2/10/12/14 indicates favorable outcomes in HCC patients and CXCL2/14 were both stably down-regulated in HCC specimens compared with adjacent normal tissues and its overexpression induced apoptosis, and played significant roles in inhibiting the proliferation, migration, and invasion of HCC cells 26. This evidence concerns the gene CXCL2 and hepatocellular carcinoma.