Metastasis associated in colon cancer 1 (MACC1) gene was first identified in 2009 as a key regulator of hepatocyte growth factor-mesenchymal-epithelial transition factor (HGF-MET) signaling and the expression of MACC1 in tumor specimens is an independent prognostic factor for colon cancer 15. The gene discussed is MACC1; the disease is malignant colon neoplasm.