For instance, downregulation of circPVT1 repressed HCC cell growth by upregulating miR-3666 to inhibit SIRT7; the increase in FAM83A expression caused by circ-ZKSCAN1 overexpression could in turn promote the expression of circ-ZKSCAN1; circ-001680 could promote the cancer stem cell population in CRC and induce irinotecan therapeutic resistance by regulating the miR-340 target gene BMI1 15-17. Here, ZKSCAN1 is linked to hepatocellular carcinoma.