EZH2 and type 1 diabetes mellitus: Their work in attempting to restore the β-cell activities in T1DM has definitely been innovative; they argue that GSK126, a potent methyltransferase inhibitor and highly selective for the histone methyltransferase EZH2, can actually inhibit pancreatic EZH2 thus restoring core β-cell markers and ductal progenitor genes [85].