Glucose-deficient tumor microenvironment limited aerobic glycolysis, and altered the production of IFN-γ, thereby impairing proliferation, cytokine production, and cytolysis of tumor-infiltrating T cells (Cham and Gajewski, 2005; Cham et al., 2008; Chang et al., 2015; Ho et al., 2015). This evidence concerns the gene IFNG and neoplasm.