Since most of the Wnt pathway-related genes, including wnt7bb, wnt1, wnt3, lypd6, and axin2 that are regulated oppositely between melanocyte regeneration and melanoma, have been associated with the Wnt/β-catenin pathway, we decided to modify the β-catenin-dependent (canonical) Wnt signaling among the Wnt pathways (Jho et al., 2002; Grumolato et al., 2010; Özhan et al., 2013; Arensman et al., 2014). This evidence concerns the gene AXIN2 and melanoma.