The majority of the Wnt pathway-related genes including wnt7bb, wnt11r, wnt4a, wnt1, wnt16, wnt3, wnt6b, wnt7aa, wnt10a, LY6/PLAUR domain containing 6 (lypd6), and axis inhibitor protein 1 (axin2) were significantly upregulated in 1 dpa and 7 dpa but downregulated in nevi and melanoma (Figure 6B). This evidence concerns the gene WNT16 and melanoma.