TP53 and cancer: Melanoma samples were significantly enriched for the GO-BP terms related to cell proliferation, cell migration, NCC migration, development, and regeneration (Figure 5C, Supplementary Table S3) and for the KEGG pathways that harbored numerous cell metabolism activities and cancer-associated signaling pathways such as MAPK, p53, forkhead box O (FoxO) and ErbB (Supplementary Figure S5A, Supplementary Table S4).