Strikingly, our recent work has revealed a very similar outcome where the expression of several Wnt encoding genes, including WNT1, WNT7A, WNT7B, WNT8A, WNT9A and WNT10B, was strongly downregulated in glioblastoma multiforme, the most aggressive diffuse form of glioma, while many Wnt genes were upregulated during brain regeneration (Demirci et al., 2022). Here, WNT1 is linked to central nervous system cancer.