CDH2 and melanoma: Activation of Wnt/β-catenin signaling via GSK3 inhibitors, including BIO, LY2090314, Chir98014, and Chir99021, has been revealed to block the migratory and invasive behavior of melanoma cells by downregulating the expression of N-cadherin and reduces their proliferation in vitro and in vivo (John et al., 2012; Atkinson et al., 2015; Taylor et al., 2018).