For instance, perturbation of tumor-endothelial adhesion molecules such as E-selectin, CD44, PODXL, VCAM1 or ICAM1 could decrease the rate of heterotypic interaction under shear flow, resulting in lower tumor cell retention rates in the circulation and limitation of metastatic seeding at the distant site (Rosette et al., 2005; Zen et al., 2008). This evidence concerns the gene PODXL and neoplasm.