17 KEGG signaling pathways were enriched by DEGs of 3 k peptides, including Metabolic pathways, Protein digestion and absorption, MAPK signaling pathway, Oxytocin signaling pathway, cGMP-PKG signaling pathway, Olfactory transduction, Huntington’s disease, Focal adhesion, PI3K-Akt signaling pathway, Pathways in cancer, ABC transporters, ECM-receptor interaction, Purine metabolism, Calcium signaling pathway, Transcriptional misregulation in cancer, Regulation of actin cytoskeleton and HTLV-I infection (Table 4). This evidence concerns the gene AKT1 and juvenile Huntington disease.