TMPRSS2 and prostate cancer: That is the case for several primary and metastatic prostate cancer cell lines, where SVs-mediated DNA loci transition from the inactive to active compartment and vice versa can cause the fusion of TMPRSS2-ERG genes - a marker used for prostate cancer malignancy stratification - (San Martin et al., 2021), and the activation of numerous genes linked to carcinogenesis (i.e., WNT5, TMPRS, and CDK44) (San Martin et al., 2021) (Table 1).