That is the case for several primary and metastatic prostate cancer cell lines, where SVs-mediated DNA loci transition from the inactive to active compartment and vice versa can cause the fusion of TMPRSS2-ERG genes - a marker used for prostate cancer malignancy stratification - (San Martin et al., 2021), and the activation of numerous genes linked to carcinogenesis (i.e., WNT5, TMPRS, and CDK44) (San Martin et al., 2021) (Table 1). This evidence concerns the gene ERG and Familial prostate cancer.