Of these, miR-10a, miR-21, miR-29a and miR-92a were able to induce myeloid cell differentiation and expansion by targeting the Rora/IκBα/NF-κB, Pten/PI3K/AKT, Hbp1/cell cycle and Prkar1a/PKA/p-STAT3 pathways, respectively, promoting their immunosuppressive functions in glioma-bearing mice (Guo et al., 2018; Guo et al., 2019). The gene discussed is AKT1; the disease is central nervous system cancer.