Thus, after interacting with tumor cells, TAMs cannot engage an efficient immune response, and show M2-like phenotypic activation changes with increase in the release of anti-inflammatory cytokines, such as IL-10 and TGF–β, arginase-1 (Arg-1), and matrix metalloproteinases, thus supporting growth and invasion associated with tumor progression (Feng et al., 2022). This evidence concerns the gene TGFB1 and neoplasm.