It has been shown that, compared to N-GDEVs, H-GDEVs contain higher levels of both IL-6 and miR-155-3p, and induce M2-like macrophage polarization via the IL-6-pSTAT3-miR-155-3p-autophagy-pSTAT3 positive feedback loop, promoting glioma progression (Xu et al., 2021). Here, IL6 is linked to central nervous system cancer.