When incubated with NHA cells, a type of normal human brain astrocytes, GDEVs were efficiently delivered and lncRNA-ATB activated astrocytes through the suppression of miR-204-3p, thus stimulating the secretion of TGF-β and glioma cell migration and invasion (Bian et al., 2019). This evidence concerns the gene TGFB1 and central nervous system cancer.