The same study has also shown that the anti-tumoral effects of miR-15a and miR-92a are mediated by the downregulation of their direct targets Ccnd1 and Rap1b, respectively, thereby blocking the PI3K/AKT/mTOR signaling pathway, known to promote glioma invasion and migration (Yao et al., 2021). This evidence concerns the gene AKT1 and glioma.