Impaired clearance of damaged mitochondria has been reported in the LCWE-induced murine model of KD vasculitis, shown by a decreased autophagic flux and blockade of autophagy by mTOR pathway activity, contributing to NLRP3 inflammasome activation and ROS accumulation (Marek-Iannucci et al., 2021). The gene discussed is NLRP3; the disease is vasculitis.