It has been reported that cardiomyocytes lacking the circadian rhythm activation factor basic helix-loop-helix ARNT like 1 (BMAL1) gene exhibit a dilated cardiomyopathy-like phenotype with reduced expression of mitochondrial BCL2 interacting protein 3 (BNIP3) protein, resulting in defective mitophagy and cardiomyocyte function (Li et al., 2020). Here, BMAL1 is linked to dilated cardiomyopathy.