ERN1 and vasculitis: In addition, alleviating ER stress in mice by deletion or pharmacological inhibition of ER resident endoribonuclease IRE1 also reduces LCWE-induced KD vasculitis as well as caspase-1 activity and IL-1β production, highlighting the importance of ER stress pathways in KD progression (Marek-Iannucci et al., 2022).