TREM2 and Mental deterioration: Regional specificity of TREM2 expression in a postmortem analysis of primarily non-Hispanic whites, where cortical TREM2 levels were positively associated with AD diagnosis, cognitive decline, and amyloid beta neuropathology, and caudal TREM2 Levels are inversely related to AD neuropathology, indicating that the association of trem2 with Tau burden may depend on disease status (Winfree et al., 2023).