Additionally, INO80 is required for H2A.Z dynamics in ER signaling, and silencing of INO80 reduces stimulation of endogenous GREB1 and TFF1 enhancers in breast cancer (García-Pedrero et al., 2006; Papamichos-Chronakis et al., 2011; Segala et al., 2016). Here, TFF1 is linked to breast cancer.