ESR1 and triple-negative breast carcinoma: Based on INO80 CNV and IHC status, the unsupervised clustering identified three clusters: the primary luminal (cluster 1), mainly composed of patients with ER+/PR+/HER2-status; the primary HER2+ (cluster 2), mainly composed of patients with ER-/PR-/HER2+ status; and the primary triple-negative breast cancer (TNBC) (cluster 3), mainly composed of patients with ER-/PR-/HER2-status (Figure 2C).