INO80 and breast carcinoma: Given the significant increase in the risk of breast cancer and decreased survival rate observed in patients with INO80 complex dysfunction (Figure 1C), as well as the need for further investigation into the association between INO80 deregulation and breast cancer, WGCNA was performed to investigate gene expression, CNV, and clinical IHC annotations of INO80 in patients with breast cancer (Cancer Genome Atlas Network, 2012; Ciriello et al., 2015) followed the workflow in Supplementary Figure S2A.