Previous studies have demonstrated the involvement of INO80 in stem cell differentiation and mammary tumors via the Wnt pathway (Wang et al., 2014a; Zhou et al., 2016b; Zhang et al., 2017; Timmermans-Sprang et al., 2019) and its regulation of BMP signaling in embryonic and liver cancer stem cells (Hens et al., 2007; Qiu et al., 2016; Wang et al., 2019). This evidence concerns the gene INO80 and liver cancer.