THSD4 and breast cancer: THSD4 and TBC1D9 are two factors that drive TNBC, and their expression is also linked to the epithelial–mesenchymal transition (EMT), metastatic dissemination, and the plasticity of breast cancer cells (Cohen et al., 2014; Kothari et al., 2020; Miao et al., 2020; Kothari et al., 2021).