Baicalein, a bioactive flavonoid found in Scutellaria baicalensis, exerts its effects on PD treatment by inhibiting microglial pyroptosis through the NLRP3/GSDMD pathway, reducing dopaminergic neuronal loss, and suppressing pro-inflammatory cytokine increase (Wang J. et al., 2022). This evidence concerns the gene NLRP3 and Parkinson disease.