Jiedu-Yizhi formula reduces the expression of NLRP3, pro-caspase-1, and caspase-1 P20 proteins in the hippocampus of AD rats, inhibiting excessive activation of the NLRP3 inflammasome, suppressing GSDMD maturation, breaking the vicious cycle between Amyloid-beta and pyroptosis, and improving cognitive impairment in AD rats (Wang J. et al., 2022). This evidence concerns the gene CASP1 and Cognitive impairment.