Salidroside, a natural compound found in certain plants, such as Rhodiola rosea and alpine rhododendron, has been found to reduce and inhibit microglial pyroptosis by lowering IL-1β and IL-18 expression, as well as reversing the elevated levels of TLR4, NF-κB, NLRP3, ASC, cleaved caspase-1, and cleaved GSDMD proteins in an AD mouse model (Cai et al., 2021). Here, TLR4 is linked to Alzheimer disease.