MCC950 is a small molecule that inhibits the formation of the inflammasome by blocking NLRP3 activation, thereby inhibiting caspase-1 activation and microglial pyroptosis induced by LPS, reducing neurotoxic α-syn accumulation, dopaminergic neuronal damage, and improving behavioral deficits in a PD rat model (Wang R. et al., 2023). Here, CASP1 is linked to Parkinson disease.