In PD rat models induced by lipopolysaccharide (LPS) and 6-hydroxydopamine, it was found that the NLRP3 inflammasome components were highly expressed in microglia, and this result was reversed by the caspase-1 inhibitor (Ac-YVAD-CMK; Voet et al., 2019). This evidence concerns the gene NLRP3 and Parkinson disease.