LRP1 and Cognitive impairment: A recent study showed that deletion of brain endothelial LRP1 leads to loss of BBB integrity, neuronal loss, and cognitive deficits in Lrp1lox/lox mice (an endothelial-specific Lrp1 knockout mouse) and that these deficits can be reversed by endothelial-specific LRP1 gene therapy (Nikolakopoulou et al., 2021).