TREM2 and Alzheimer disease: For example, strategies that augment the function of microglia (the key immune effector cells in the brain), such as Sargramostim/Leukine (Potter et al., 2021) and TREM2-targeting mAbs such as AL002 and ATV:TREM2 (Paul et al., 2021; Ward et al., 2021; van Lengerich et al., 2023), have the potential to modify many of the mechanisms underlying AD.