The primary endpoint of the trial was the change from baseline to 76 weeks in Integrated Alzheimer’s Disease Rating Scale (iADRS) scores and secondary endpoints included changes in CDR-SB scores and other cognitive assessments, amyloid PET scans, tau PET scans, and volumetric MRI (magnetic resonance imaging) scans (Zimmer et al., 2022; Eli Lilly and Company, 2023). The gene discussed is MAPT; the disease is Alzheimer disease.