Evidence suggests that autophagy, along with its non-canonical processes such as LC3-associated phagocytosis (LAP) and LC3-associated non-canonical autophagy-dependent necroptosis (LANDO), plays a significant role in the development of AD (Hooper et al., 2021; Magne and Green, 2022). The gene discussed is MAP1LC3A; the disease is Alzheimer disease.