APOE, the gene encoding apolipoprotein E, is the greatest genetic risk factor with APOE4 increasing risk up to 15-fold compared to APOE3 (Corder et al., 1993; Strittmatter et al., 1993), and APOE4 is also associated with earlier age of AD onset (Corder et al., 1993; Locke et al., 1995; Bilgel et al., 2016; Polsinelli et al., 2023a). This evidence concerns the gene APOE and Alzheimer disease.