Through our comprehensive analysis, we identified three key CNVs (i.e., DEL5006, mCNV14192, and DUP42180) that regulate the expression of seven genes (i.e., PLGRKT, TLR1, PLAU, CALB2, SYTL2, OTOF, and NT5DC1) ultimately impacting the age of death of AD patients. Here, TLR1 is linked to Alzheimer disease.