Through our comprehensive analysis, we identified three key CNVs (i.e., DEL5006, mCNV14192, and DUP42180) that regulate the expression of seven genes (i.e., PLGRKT, TLR1, PLAU, CALB2, SYTL2, OTOF, and NT5DC1) ultimately impacting the age of death of AD patients. The gene discussed is PLAU; the disease is Alzheimer disease.