Meanwhile, the copy number dosage of the other two CNVs, which are DUP42180 and mCNV14192, were negatively correlated with AOD through regulating the expression of genes OTOF, SYTL2, CALB2, and PLAU. Interestingly, we further found two AD-risk genes, PLAU and TLR1, which functions in the Aβ clearance and degradation process (Ertekin-Taner et al., 2005; Liu et al., 2012) were positively correlated with AOD of AD patients. Here, PLAU is linked to Alzheimer disease.