Proteomics analysis of serum samples from sedentary and low‐dose exercise mice revealed seven upregulated circulating proteins and the contents of insulin‐like growth factor 1 (IGF‐1) and hyaluronan binding protein 2 (HABP2) were highly associated with the expression of cardiac CTRP9 in mice with established MI (Figure 5C). This evidence concerns the gene HABP2 and myocardial infarction.