Similarly, in CD16+ cells (Figure S5A), the Alpha strain infection induced continuous upregulation of IFI16, IFI27, NOTCH2, LGALS3, KCNH7, IFIT2, ADAR, IFIT3, HCK, TRIM5 and STAT2, and ALPK1, TRIM22, STAT1, EPSTI1, OAS2, PML, and IFI44 were continuously upregulated in Beta strain‐infected animal. The gene discussed is ALPK1; the disease is infection.