Overall, strong immune responses occurred at 1 dpi and then decreased in the following days, including the frequencies of immune cell populations (Figures 1E and F), COVID‐19‐related genes and signal pathways (Figures 2 and 3), COVID‐19‐related genes intersected with a study including a very large patient samples, and 16 genes (IFI27, IFI44L, IFIT1, OAS3, DDX60, OAS2, XAF1, ISG15, RSAD2, HERC5, MX1, IFI6, IFIT3, IFI44, IFIT2, and OAS1) overlapped with them, suggesting that rhesus monkeys can mimic human infection with SARS‐CoV‐2.29 Here, ISG15 is linked to infection.