The expression levels of inflammatory genes show complex correlations to a certain extent, ultimately leading to the rampant proliferation of inflammatory gene profiles (such as NLRP3, NLRC4, NOD, IL‐1β, and IL‐18), while in sepsis studies, the same gene regulation pattern was observed with a higher amplitude of change, revealing its clinical correlation with the severity of sepsis.39, 120, 121. Here, IL18 is linked to Sepsis.