Although autophagy levels were regulated by the severity of sepsis, mitochondrial biogenesis was successfully restored by injection of cell‐permeable TATI‐beclin‐1 through the PINK1/Parkin and AMP‐activated protein kinase (AMPK)/Unc‐51‐like protein kinase 1 signaling pathways and maintained sepsis cardiac function.264. Here, PRKN is linked to Sepsis.