DDIT3 and Multiple Organ Failure: In sepsis animal models, markers of increased ER stress (such as glucose‐regulated protein 94 [GRP94], CEBP homologous protein [CHOP], and caspase‐12) are detected in several organs, including the heart and liver, and these markers are directly connected with the extent of organ dysfunction, which may be a major cause of sepsis‐induced multiple organ failure.234, 235, 236