HMGB1 and Sepsis: In the sepsis‐induced inflammatory response, both external factors derived from pathogens and internal factors released by damaged cells (such as lipopolysaccharide [LPS] and high‐mobility group box‐1 [HMGB‐1] protein) can recognize PRRs, including Toll‐like receptors (TLRs), C‐type lectin receptors (CLRs), retinoic acid inducible gene I (RIG‐I)‐like receptors, and NOD‐like receptors (NLRs), leading to the activation of downstream pathways.39