We confirmed the previous observation that the leading SNPs in the IL12B, IL18RAP, IL23R, and TNFSF15 genes showed discordant effects on the risk between leprosy and inflammatory bowel disease (IBD), Crohn's disease (CD), and ulcerative colitis (UC), whereas the leading SNP in the LACC1 gene showed concordant effects on the risk between leprosy and IBD and CD. The gene discussed is TNFSF15; the disease is leprosy.