Moreover, the known susceptibility genes identified by their reported function of immune regulation previously, like IL18RAP, IL12B, NOD2, IL27, and TNFSF15, were also highlighted in the 15 established loci by comprehensive fine‐mapping methods here, which further confirmed the precision of our fine‐mapping strategy and the immune‐associated mechanisms in leprosy, providing a foundation for further functional exploration and interpretation of the pathogenesis. This evidence concerns the gene IL27 and leprosy.