Thus, the leprosy susceptibility loci, including NOD2, RIPK2, TNFSF15, LACC1, LRRK2, IL12B, and HLA‐DR in phagocytes and IL23R, TYK2, and CSK in T cells, may interfere with the synergistic antimicrobial response between phagocytes and T cells. The gene discussed is TNFSF15; the disease is leprosy.