To systematically illustrate the molecular mechanisms underlying leprosy, on the basis of the functional annotation of previously identified causal genes including NOD2, RIPK2, TNFSF15, LACC1, IL12B, HLA‐DR, IL23R, LRRK2, and TYK26, 10, 13, 18 and the newly pinpointed candidate gene CSK, we speculated that these variants may interfere with the recognition, presentation, and clearance of M. leprae. This evidence concerns the gene IL12B and leprosy.