While intracranial lesions in patients with GFAP-IgG-associated myelitis in our study were found in the cortical/subcortical, medulla oblongata, lateral ventricles, thalamus, pons, and basal ganglia, among others, nine of them had cranial MRI enhancement scans, although this typical enhancement was not observed. The gene discussed is GFAP; the disease is myelitis.